Interações medicamentosas
Isosorbide dinitrate + Methylergonovine
Gravidade: Grave
Isosorbide dinitrate and Methylergonovine: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Methylergonovine is a vasoconstrictor that can oppose the antianginal and vasodilator effects of nitrates. Ergot-induced coronary vasospasm may precipitate angina and may raise blood pressure.
O que esta interação significa em palavras simples
Isosorbide dinitrate and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Pharmacodynamic antagonism: ergot vasoconstriction opposes nitrate vasodilation.
O que fazer
Avoid where possible, especially in patients with coronary disease. If methylergonovine is essential, monitor blood pressure and chest pain closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicada
- Isosorbide dinitrate + Riociguat Contraindicada
- Isosorbide dinitrate + Sildenafil Contraindicada
- Isosorbide dinitrate + Tadalafil Contraindicada
- Isosorbide dinitrate + Vardenafil Contraindicada
- Ergotamine + Isosorbide dinitrate Grave
Perguntas frequentes
Can I take Isosorbide dinitrate with Methylergonovine?
MediHelp rates the interaction as major. Isosorbide dinitrate and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methylergonovine is a vasoconstrictor that can oppose the antianginal and vasodilator effects of nitrates. Ergot-induced coronary vasospasm may precipitate angina and may raise blood pressure.
How serious is the interaction between Isosorbide dinitrate and Methylergonovine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible, especially in patients with coronary disease. If methylergonovine is essential, monitor blood pressure and chest pain closely.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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