Interações medicamentosas
Ergotamine + Isosorbide dinitrate
Gravidade: Grave
Ergotamine and Isosorbide dinitrate: major interaction.
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Resumo
Ergotamine causes vasoconstriction and can provoke angina or raise blood pressure, opposing the antianginal action of nitrates. Nitrates may also be less effective, and the clinical effect is loss of antianginal efficacy and ischaemia risk.
O que esta interação significa em palavras simples
Ergotamine and Isosorbide dinitrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Isosorbide dinitrate belongs to Cardiovascular.
Por que acontece
Pharmacodynamic antagonism between ergotamine vasoconstriction and nitrate vasodilation.
O que fazer
Avoid in patients with coronary disease; use a non-ergot migraine therapy where possible, and monitor for angina and blood pressure rise if unavoidable.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicada
- Isosorbide dinitrate + Riociguat Contraindicada
- Isosorbide dinitrate + Sildenafil Contraindicada
- Isosorbide dinitrate + Tadalafil Contraindicada
- Isosorbide dinitrate + Vardenafil Contraindicada
- Isosorbide dinitrate + Methylergonovine Grave
Outras interações de Ergotamine
- Almotriptan + Ergotamine Contraindicada
- Atazanavir + Ergotamine Contraindicada
- Clarithromycin + Ergotamine Contraindicada
- Cobicistat + Ergotamine Contraindicada
- Darunavir + Ergotamine Contraindicada
- Dihydroergotamine intranasal + Ergotamine Contraindicada
Perguntas frequentes
Can I take Ergotamine with Isosorbide dinitrate?
MediHelp rates the interaction as major. Ergotamine and Isosorbide dinitrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergotamine causes vasoconstriction and can provoke angina or raise blood pressure, opposing the antianginal action of nitrates. Nitrates may also be less effective, and the clinical effect is loss of antianginal efficacy and ischaemia risk.
How serious is the interaction between Ergotamine and Isosorbide dinitrate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with coronary disease; use a non-ergot migraine therapy where possible, and monitor for angina and blood pressure rise if unavoidable.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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