Interações medicamentosas
Isosorbide dinitrate + Vardenafil
Gravidade: Contraindicada
Isosorbide dinitrate and Vardenafil: contraindicated interaction.
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Resumo
Vardenafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
O que esta interação significa em palavras simples
Isosorbide dinitrate and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide dinitrate belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Por que acontece
PDE5 inhibition potentiates nitrate-induced cGMP vasodilation
O que fazer
Contraindicated; do not give a nitrate within 24 hours of vardenafil, and use an alternative if both are required.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Vardenafil
- Amyl nitrite + Vardenafil Contraindicada
- Glyceryl trinitrate pr + Vardenafil Contraindicada
- Isosorbide mononitrate + Vardenafil Contraindicada
- Nicorandil + Vardenafil Contraindicada
- Nitroglycerin po + Vardenafil Contraindicada
- Nitroglycerin rectal + Vardenafil Contraindicada
Outras interações de Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicada
- Isosorbide dinitrate + Riociguat Contraindicada
- Isosorbide dinitrate + Sildenafil Contraindicada
- Isosorbide dinitrate + Tadalafil Contraindicada
- Ergotamine + Isosorbide dinitrate Grave
- Isosorbide dinitrate + Methylergonovine Grave
Perguntas frequentes
Can I take Isosorbide dinitrate with Vardenafil?
MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vardenafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
How serious is the interaction between Isosorbide dinitrate and Vardenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give a nitrate within 24 hours of vardenafil, and use an alternative if both are required.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide mononitrate. The full list is on the Vardenafil page.
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