Interações medicamentosas
Azathioprine + Mesalamine
Gravidade: Moderada
Azathioprine and Mesalamine: moderate interaction.
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Resumo
Mesalamine may inhibit thiopurine methyltransferase, raising active thioguanine nucleotide levels. This can increase the risk of leukopenia and other myelosuppression.
O que esta interação significa em palavras simples
Azathioprine and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Mesalamine belongs to Gastrointestinal Tract.
Por que acontece
Inhibition of TPMT by mesalamine increases thiopurine metabolite exposure.
O que fazer
Monitor complete blood counts regularly and reduce azathioprine dose if leukopenia develops.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Mesalamine
Outras interações de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicada
- Azathioprine + Bcg vaccine live Contraindicada
- Azathioprine + Febuxostat Contraindicada
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Azathioprine + Measles mumps and rubella vaccine Contraindicada
- Azathioprine + Measles mumps and rubella vaccine live Contraindicada
Perguntas frequentes
Can I take Azathioprine with Mesalamine?
MediHelp rates the interaction as moderate. Azathioprine and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine may inhibit thiopurine methyltransferase, raising active thioguanine nucleotide levels. This can increase the risk of leukopenia and other myelosuppression.
How serious is the interaction between Azathioprine and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce azathioprine dose if leukopenia develops.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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