Interações medicamentosas
Bismuth subsalicylate + Omadacycline
Gravidade: Moderada
Bismuth subsalicylate and Omadacycline: moderate interaction.
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Resumo
Bismuth in bismuth subsalicylate can chelate oral omadacycline and reduce its absorption. This may lower antibiotic exposure and efficacy.
O que esta interação significa em palavras simples
Bismuth subsalicylate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Omadacycline belongs to Anti Bacterial.
Por que acontece
Chelation of omadacycline by polyvalent bismuth cations in the GI tract reduces absorption.
O que fazer
Avoid taking omadacycline within several hours of bismuth subsalicylate; labeling advises waiting at least 4 hours after omadacycline before polyvalent-cation products. Monitor clinical response.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Grave
- Bismuth subsalicylate + Warfarin Grave
- Acetylsalicylic acid + Bismuth subsalicylate Moderada
- Amlodipine-benazepril + Bismuth subsalicylate Moderada
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderada
- Aspirin rectal + Bismuth subsalicylate Moderada
Outras interações de Omadacycline
- Acitretin + Omadacycline Contraindicada
- Isotretinoin + Omadacycline Grave
- Omadacycline + Tretinoin Grave
- Aluminum hydroxide + Omadacycline Moderada
- Amoxicillin-clavulanic acid + Omadacycline Moderada
- Amoxicillin + Omadacycline Moderada
Perguntas frequentes
Can I take Bismuth subsalicylate with Omadacycline?
MediHelp rates the interaction as moderate. Bismuth subsalicylate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth in bismuth subsalicylate can chelate oral omadacycline and reduce its absorption. This may lower antibiotic exposure and efficacy.
How serious is the interaction between Bismuth subsalicylate and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking omadacycline within several hours of bismuth subsalicylate; labeling advises waiting at least 4 hours after omadacycline before polyvalent-cation products. Monitor clinical response.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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