Interações medicamentosas
Cefotaxime + Tobramycin
Gravidade: Moderada
Cefotaxime and Tobramycin: moderate interaction.
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Resumo
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with cefotaxime is modest and mainly relevant in patients with renal impairment, older age or dehydration.
O que esta interação significa em palavras simples
Cefotaxime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotaxime belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Por que acontece
Possible additive nephrotoxicity, with reduced renal function leading to higher aminoglycoside exposure and greater ototoxic potential.
O que fazer
Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefotaxime
- Cefotaxime + Typhoid vaccine live Grave
- Amikacin + Cefotaxime Moderada
- Cefotaxime + Cholera vaccine Moderada
- Cefotaxime + Dexamethasone-tobramycin Moderada
- Cefotaxime + Gentamicin Moderada
- Cefotaxime + Kanamycin Moderada
Outras interações de Tobramycin
- Cidofovir + Tobramycin Contraindicada
- Adefovir + Tobramycin Grave
- Amikacin + Tobramycin Grave
- Amphotericin b deoxycholate + Tobramycin Grave
- Amphotericin b + Tobramycin Grave
- Atracurium + Tobramycin Grave
Perguntas frequentes
Can I take Cefotaxime with Tobramycin?
MediHelp rates the interaction as moderate. Cefotaxime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with cefotaxime is modest and mainly relevant in patients with renal impairment, older age or dehydration.
How serious is the interaction between Cefotaxime and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
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