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Interações medicamentosas

Celecoxib + Prasugrel

Gravidade: Grave

Celecoxib and Prasugrel: major interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Combining an NSAID with prasugrel increases the risk of bleeding, particularly gastrointestinal bleeding. Prasugrel already carries a substantial bleeding risk.

O que esta interação significa em palavras simples

Celecoxib and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Celecoxib belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.

Nível de evidência: Moderate

Por que acontece

Additive effect of irreversible P2Y12 platelet inhibition and NSAID-related platelet dysfunction and mucosal injury.

O que fazer

Avoid chronic NSAID use where possible and use paracetamol as an alternative. If needed, use the lowest celecoxib dose briefly with a proton pump inhibitor and monitor for bleeding.

O que perguntar ao farmacêutico

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Celecoxib with Prasugrel?

MediHelp rates the interaction as major. Celecoxib and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with prasugrel increases the risk of bleeding, particularly gastrointestinal bleeding. Prasugrel already carries a substantial bleeding risk.

How serious is the interaction between Celecoxib and Prasugrel?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use where possible and use paracetamol as an alternative. If needed, use the lowest celecoxib dose briefly with a proton pump inhibitor and monitor for bleeding.

What other medicines interact with Celecoxib?

MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.

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