Interações medicamentosas
Charcoal + Methotrexate
Gravidade: Moderada
Charcoal and Methotrexate: moderate interaction.
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Resumo
Activated charcoal adsorbs methotrexate in the gut and interrupts its enterohepatic circulation, decreasing exposure. This can reduce therapeutic effect with routine use but can help limit toxicity in overdose.
O que esta interação significa em palavras simples
Charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Charcoal belongs to Gastrointestinal Tract; Methotrexate belongs to Oncology.
Por que acontece
Charcoal binds methotrexate in the gastrointestinal lumen, reducing absorption and biliary reabsorption.
O que fazer
Do not give charcoal with oral methotrexate therapy; separate doses by several hours if charcoal is needed. In toxicity, charcoal may be used alongside leucovorin and monitoring of methotrexate levels and renal function.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Charcoal
- Charcoal + Citalopram Moderada
- Charcoal + Digoxin Moderada
- Charcoal + Leflunomide Moderada
- Charcoal + Theophylline Moderada
- Charcoal + Tiratricol Moderada
- Acarbose + Charcoal Leve
Outras interações de Methotrexate
- Acitretin + Methotrexate Contraindicada
- Adenovirus types 4 and 7 live + Methotrexate Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicada
- Ketorolac + Methotrexate Contraindicada
- Measles mumps and rubella vaccine live + Methotrexate Contraindicada
- Measles mumps and rubella vaccine + Methotrexate Contraindicada
Perguntas frequentes
Can I take Charcoal with Methotrexate?
MediHelp rates the interaction as moderate. Charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Activated charcoal adsorbs methotrexate in the gut and interrupts its enterohepatic circulation, decreasing exposure. This can reduce therapeutic effect with routine use but can help limit toxicity in overdose.
How serious is the interaction between Charcoal and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give charcoal with oral methotrexate therapy; separate doses by several hours if charcoal is needed. In toxicity, charcoal may be used alongside leucovorin and monitoring of methotrexate levels and renal function.
What other medicines interact with Charcoal?
MediHelp also lists interactions of Charcoal with, for example, Citalopram, Digoxin, Leflunomide. The full list is on the Charcoal page.
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