Interações medicamentosas
Charcoal + Digoxin
Gravidade: Moderada
Charcoal and Digoxin: moderate interaction.
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Resumo
Activated charcoal adsorbs oral digoxin and interrupts its enterohepatic recirculation, lowering serum levels. This is helpful in digoxin toxicity but can reduce efficacy if given at therapeutic doses.
O que esta interação significa em palavras simples
Charcoal and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Charcoal belongs to Gastrointestinal Tract; Digoxin belongs to Cardiovascular.
Por que acontece
Charcoal binds digoxin in the gut, decreasing absorption and enterohepatic recycling.
O que fazer
Avoid charcoal in routine therapy or separate it from digoxin by several hours. In digoxin poisoning, charcoal is appropriate along with digoxin-specific antibody fragments and monitoring of levels and potassium.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Charcoal
- Charcoal + Citalopram Moderada
- Charcoal + Leflunomide Moderada
- Charcoal + Methotrexate Moderada
- Charcoal + Theophylline Moderada
- Charcoal + Tiratricol Moderada
- Acarbose + Charcoal Leve
Outras interações de Digoxin
- Digoxin + Lily of the valley Contraindicada
- Digoxin + Squill Contraindicada
- Adagrasib + Digoxin Grave
- Amiodarone + Digoxin Grave
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Grave
- Amphotericin b deoxycholate + Digoxin Grave
Perguntas frequentes
Can I take Charcoal with Digoxin?
MediHelp rates the interaction as moderate. Charcoal and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Activated charcoal adsorbs oral digoxin and interrupts its enterohepatic recirculation, lowering serum levels. This is helpful in digoxin toxicity but can reduce efficacy if given at therapeutic doses.
How serious is the interaction between Charcoal and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid charcoal in routine therapy or separate it from digoxin by several hours. In digoxin poisoning, charcoal is appropriate along with digoxin-specific antibody fragments and monitoring of levels and potassium.
What other medicines interact with Charcoal?
MediHelp also lists interactions of Charcoal with, for example, Citalopram, Leflunomide, Methotrexate. The full list is on the Charcoal page.
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