Interações medicamentosas
Ciprofloxacin + Magnesium hydroxide
Gravidade: Grave
Ciprofloxacin and Magnesium hydroxide: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Magnesium in antacids chelates ciprofloxacin in the gut and markedly reduces its absorption. This can lead to subtherapeutic antibiotic levels and treatment failure or resistance.
O que esta interação significa em palavras simples
Ciprofloxacin and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Magnesium hydroxide belongs to Gastrointestinal Tract.
Por que acontece
Chelation of ciprofloxacin by polyvalent magnesium cations in the gastrointestinal tract reduces absorption.
O que fazer
Give oral ciprofloxacin at least 2 hours before or 6 hours after magnesium hydroxide. Use a non-cation alternative where possible.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Magnesium hydroxide
Outras interações de Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicada
- Ciprofloxacin + Fezolinetant Contraindicada
- Ciprofloxacin + Thioridazine Contraindicada
- Ciprofloxacin + Tizanidine Contraindicada
- Ciprofloxacin + Vandetanib Contraindicada
- Alosetron + Ciprofloxacin Grave
Perguntas frequentes
Can I take Ciprofloxacin with Magnesium hydroxide?
MediHelp rates the interaction as major. Ciprofloxacin and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium in antacids chelates ciprofloxacin in the gut and markedly reduces its absorption. This can lead to subtherapeutic antibiotic levels and treatment failure or resistance.
How serious is the interaction between Ciprofloxacin and Magnesium hydroxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral ciprofloxacin at least 2 hours before or 6 hours after magnesium hydroxide. Use a non-cation alternative where possible.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Dolutegravir, Gemifloxacin, Levofloxacin. The full list is on the Magnesium hydroxide page.
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