Interações medicamentosas
Dolutegravir + Magnesium hydroxide
Gravidade: Grave
Dolutegravir and Magnesium hydroxide: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Magnesium binds dolutegravir in the gut and substantially lowers its absorption. Reduced exposure may cause virologic failure and integrase resistance.
O que esta interação significa em palavras simples
Dolutegravir and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolutegravir belongs to Anti Virals; Magnesium hydroxide belongs to Gastrointestinal Tract.
Por que acontece
Chelation of dolutegravir by polyvalent magnesium cations in the gastrointestinal tract.
O que fazer
Take dolutegravir 2 hours before or 6 hours after magnesium hydroxide. Monitor viral load if timing cannot be maintained.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Magnesium hydroxide
Outras interações de Dolutegravir
Perguntas frequentes
Can I take Dolutegravir with Magnesium hydroxide?
MediHelp rates the interaction as major. Dolutegravir and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium binds dolutegravir in the gut and substantially lowers its absorption. Reduced exposure may cause virologic failure and integrase resistance.
How serious is the interaction between Dolutegravir and Magnesium hydroxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir 2 hours before or 6 hours after magnesium hydroxide. Monitor viral load if timing cannot be maintained.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Magnesium hydroxide page.
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