Interações medicamentosas
Clobazam + Orlistat
Gravidade: Moderada
Clobazam and Orlistat: moderate interaction.
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Resumo
Orlistat reduces fat absorption and has been associated with lower levels of some antiepileptics, with reports of breakthrough seizures. A similar effect on lipophilic clobazam is possible but not well documented.
O que esta interação significa em palavras simples
Clobazam and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Orlistat belongs to Miscellaneous.
Por que acontece
Possible reduced gastrointestinal absorption of lipophilic drugs due to lipase inhibition; not firmly established for clobazam.
O que fazer
Monitor seizure control when starting or stopping orlistat. Consider separating doses by at least 2 hours.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Orlistat
- Cyclosporine + Orlistat Grave
- Cyclosporin + Orlistat Grave
- Orlistat + Triheptanoin Grave
- Amiodarone + Orlistat Moderada
- Beta carotene + Orlistat Moderada
- Carbamazepine + Orlistat Moderada
Outras interações de Clobazam
- Amobarbital + Clobazam Grave
- Buprenorphine + Clobazam Grave
- Butorphanol + Clobazam Grave
- Carisoprodol + Clobazam Grave
- Chloral hydrate + Clobazam Grave
- Clobazam + Clozapine Grave
Perguntas frequentes
Can I take Clobazam with Orlistat?
MediHelp rates the interaction as moderate. Clobazam and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat reduces fat absorption and has been associated with lower levels of some antiepileptics, with reports of breakthrough seizures. A similar effect on lipophilic clobazam is possible but not well documented.
How serious is the interaction between Clobazam and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control when starting or stopping orlistat. Consider separating doses by at least 2 hours.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporine, Cyclosporin, Triheptanoin. The full list is on the Orlistat page.
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