Interações medicamentosas
Cobicistat + Flutamide
Gravidade: Moderada
Cobicistat and Flutamide: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cobicistat is a strong CYP3A4 inhibitor and may raise flutamide exposure, although flutamide is mainly cleared by CYP1A2. Higher levels of flutamide or its metabolites could increase the risk of hepatotoxicity.
O que esta interação significa em palavras simples
Cobicistat and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Flutamide belongs to Endocrine.
Por que acontece
Cobicistat inhibits CYP3A4, reducing metabolism of flutamide and its metabolites.
O que fazer
Monitor liver enzymes closely and counsel patients on symptoms of liver injury. Consider an alternative antiandrogen or antiretroviral if abnormalities arise.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Cobicistat e Flutamide, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Flutamide
Outras interações de Cobicistat
- Alfuzosin + Cobicistat Contraindicada
- Apalutamide + Cobicistat Contraindicada
- Cobicistat + Colchicine Contraindicada
- Cobicistat + Dronedarone Contraindicada
- Cobicistat + Eletriptan Contraindicada
- Cobicistat + Eplerenone Contraindicada
Perguntas frequentes
Can I take Cobicistat with Flutamide?
MediHelp rates the interaction as moderate. Cobicistat and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and may raise flutamide exposure, although flutamide is mainly cleared by CYP1A2. Higher levels of flutamide or its metabolites could increase the risk of hepatotoxicity.
How serious is the interaction between Cobicistat and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and counsel patients on symptoms of liver injury. Consider an alternative antiandrogen or antiretroviral if abnormalities arise.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
