Interações medicamentosas
Codeine + Methohexital
Gravidade: Grave
Codeine and Methohexital: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Methohexital is a barbiturate anesthetic that causes dose-dependent CNS and respiratory depression. With codeine, sedation, hypotension and respiratory depression are enhanced.
O que esta interação significa em palavras simples
Codeine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Codeine belongs to Musculoskeletal; Methohexital belongs to Central Nervous System.
Por que acontece
Additive CNS depression from GABA-A potentiation by the barbiturate and opioid receptor agonism.
O que fazer
Use only in a monitored setting with equipment for airway support. Reduce the methohexital or opioid dose and monitor respiration and blood pressure.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Codeine
- Alvimopan + Codeine Contraindicada
- Codeine + Isocarboxazid Contraindicada
- Codeine + Olanzapine / samidorphan Contraindicada
- Codeine + Phenelzine Contraindicada
- Codeine + Tranylcypromine Contraindicada
- Alfentanil + Codeine Grave
Outras interações de Methohexital
Perguntas frequentes
Can I take Codeine with Methohexital?
MediHelp rates the interaction as major. Codeine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic that causes dose-dependent CNS and respiratory depression. With codeine, sedation, hypotension and respiratory depression are enhanced.
How serious is the interaction between Codeine and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only in a monitored setting with equipment for airway support. Reduce the methohexital or opioid dose and monitor respiration and blood pressure.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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