Interações medicamentosas
Danicopan + Fluvastatin
Gravidade: Moderada
Danicopan and Fluvastatin: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Danicopan inhibits BCRP and raises exposure to BCRP substrates. Fluvastatin is partly handled by BCRP, so its concentrations may increase and raise the risk of muscle toxicity.
O que esta interação significa em palavras simples
Danicopan and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Fluvastatin belongs to Cardiovascular.
Por que acontece
Danicopan inhibits BCRP, reducing fluvastatin efflux and increasing exposure.
O que fazer
Monitor for myopathy and consider limiting the fluvastatin dose. Check creatine kinase if muscle symptoms appear.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Fluvastatin
- Cyclosporine + Fluvastatin Grave
- Cyclosporin + Fluvastatin Grave
- Fluvastatin + Gemfibrozil Grave
- Fluvastatin + Letermovir Grave
- Fluvastatin + Red yeast rice Grave
- Apalutamide + Fluvastatin Moderada
Outras interações de Danicopan
- Amiodarone + Danicopan Moderada
- Apixaban + Danicopan Moderada
- Atorvastatin + Danicopan Moderada
- Brentuximab + Danicopan Moderada
- Carvedilol + Danicopan Moderada
- Cladribine + Danicopan Moderada
Perguntas frequentes
Can I take Danicopan with Fluvastatin?
MediHelp rates the interaction as moderate. Danicopan and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP and raises exposure to BCRP substrates. Fluvastatin is partly handled by BCRP, so its concentrations may increase and raise the risk of muscle toxicity.
How serious is the interaction between Danicopan and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy and consider limiting the fluvastatin dose. Check creatine kinase if muscle symptoms appear.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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