Interações medicamentosas
Demeclocycline + Magnesium sulphate
Gravidade: Moderada
Demeclocycline and Magnesium sulphate: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Oral magnesium binds demeclocycline in the gut to form poorly absorbed complexes. This can substantially reduce tetracycline levels and cause treatment failure. The interaction applies to oral magnesium, not intravenous administration.
O que esta interação significa em palavras simples
Demeclocycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Chelation of demeclocycline by magnesium cations in the gastrointestinal tract decreases absorption.
O que fazer
Give demeclocycline at least 2 hours before or 4 to 6 hours after oral magnesium preparations. Alternatively use a non-chelating antibiotic or a non-magnesium laxative or antacid.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Magnesium sulphate
- Amikacin + Magnesium sulphate Moderada
- Amphotericin b deoxycholate + Magnesium sulphate Moderada
- Atracurium + Magnesium sulphate Moderada
- Baloxavir marboxil + Magnesium sulphate Moderada
- Ciprofloxacin + Magnesium sulphate Moderada
- Cisatracurium + Magnesium sulphate Moderada
Perguntas frequentes
Can I take Demeclocycline with Magnesium sulphate?
MediHelp rates the interaction as moderate. Demeclocycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium binds demeclocycline in the gut to form poorly absorbed complexes. This can substantially reduce tetracycline levels and cause treatment failure. The interaction applies to oral magnesium, not intravenous administration.
How serious is the interaction between Demeclocycline and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give demeclocycline at least 2 hours before or 4 to 6 hours after oral magnesium preparations. Alternatively use a non-chelating antibiotic or a non-magnesium laxative or antacid.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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