Interações medicamentosas
Dihydroergotamine intranasal + Phenylephrine
Gravidade: Grave
Dihydroergotamine intranasal and Phenylephrine: major interaction.
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Resumo
Phenylephrine is an alpha-1 agonist vasoconstrictor and dihydroergotamine also constricts blood vessels, so combined use can produce marked vasoconstriction and a rise in blood pressure. Peripheral or cerebral ischemia is possible, especially with systemic phenylephrine exposure.
O que esta interação significa em palavras simples
Dihydroergotamine intranasal and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive pharmacodynamic vasoconstriction through alpha-adrenergic agonism and ergot-mediated serotonergic and adrenergic vascular effects.
O que fazer
Avoid systemic or repeated use of phenylephrine with dihydroergotamine; choose a non-vasoconstrictor alternative. If unavoidable, monitor blood pressure and watch for ischemic symptoms.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicada
- Phenelzine + Phenylephrine Contraindicada
- Phenylephrine + Tranylcypromine Contraindicada
- Bromocriptine + Phenylephrine Grave
- Cocaine + Phenylephrine Grave
- Dihydroergotamine + Phenylephrine Grave
Perguntas frequentes
Can I take Dihydroergotamine intranasal with Phenylephrine?
MediHelp rates the interaction as major. Dihydroergotamine intranasal and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenylephrine is an alpha-1 agonist vasoconstrictor and dihydroergotamine also constricts blood vessels, so combined use can produce marked vasoconstriction and a rise in blood pressure. Peripheral or cerebral ischemia is possible, especially with systemic phenylephrine exposure.
How serious is the interaction between Dihydroergotamine intranasal and Phenylephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic or repeated use of phenylephrine with dihydroergotamine; choose a non-vasoconstrictor alternative. If unavoidable, monitor blood pressure and watch for ischemic symptoms.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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