Interações medicamentosas
Dihydroergotamine + Phenylephrine
Gravidade: Grave
Dihydroergotamine and Phenylephrine: major interaction.
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Resumo
Both drugs cause vasoconstriction, and together they can cause marked hypertension and peripheral or cerebral ischemia. The effect is most relevant with systemic phenylephrine.
O que esta interação significa em palavras simples
Dihydroergotamine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Por que acontece
Additive alpha-adrenergic and serotonergic vasoconstriction.
O que fazer
Avoid systemic phenylephrine with dihydroergotamine. If unavoidable, monitor blood pressure and for signs of ischemia such as limb coldness or chest pain.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicada
- Phenelzine + Phenylephrine Contraindicada
- Phenylephrine + Tranylcypromine Contraindicada
- Bromocriptine + Phenylephrine Grave
- Cocaine + Phenylephrine Grave
- Dihydroergotamine intranasal + Phenylephrine Grave
Outras interações de Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
- Dihydroergotamine + Dopamine Contraindicada
- Dihydroergotamine + Dronedarone Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Dihydroergotamine + Eletriptan Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine with Phenylephrine?
MediHelp rates the interaction as major. Dihydroergotamine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause vasoconstriction, and together they can cause marked hypertension and peripheral or cerebral ischemia. The effect is most relevant with systemic phenylephrine.
How serious is the interaction between Dihydroergotamine and Phenylephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic phenylephrine with dihydroergotamine. If unavoidable, monitor blood pressure and for signs of ischemia such as limb coldness or chest pain.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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