Interações medicamentosas
Phenylephrine + Tranylcypromine
Gravidade: Contraindicada
Phenylephrine and Tranylcypromine: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Tranylcypromine is an irreversible MAO inhibitor, and sympathomimetics can precipitate a hypertensive crisis. This may cause severe headache, stroke or death.
O que esta interação significa em palavras simples
Phenylephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenylephrine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Por que acontece
Inhibition of MAO enhances norepinephrine stores and the pressor response to phenylephrine.
O que fazer
Do not combine; avoid systemic phenylephrine during and for two weeks after tranylcypromine. Choose non-sympathomimetic alternatives.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
- Tranylcypromine - FDA drug label (DailyMed) — openFDA / DailyMed
Outras interações de Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicada
- Phenelzine + Phenylephrine Contraindicada
- Bromocriptine + Phenylephrine Grave
- Cocaine + Phenylephrine Grave
- Dihydroergotamine intranasal + Phenylephrine Grave
- Dihydroergotamine + Phenylephrine Grave
Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Phenylephrine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Phenylephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine is an irreversible MAO inhibitor, and sympathomimetics can precipitate a hypertensive crisis. This may cause severe headache, stroke or death.
How serious is the interaction between Phenylephrine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid systemic phenylephrine during and for two weeks after tranylcypromine. Choose non-sympathomimetic alternatives.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Bromocriptine. The full list is on the Phenylephrine page.
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