Interações medicamentosas
Isocarboxazid + Phenylephrine
Gravidade: Contraindicada
Isocarboxazid and Phenylephrine: contraindicated interaction.
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Resumo
Isocarboxazid irreversibly inhibits monoamine oxidase, and phenylephrine is a direct alpha-1 agonist; with MAO inhibition pressor response is potentiated because MAO inhibition reduces catecholamine breakdown and sensitises tissues. Heart-rate and blood pressure rises, arrhythmia or a hypertensive crisis can result.
O que esta interação significa em palavras simples
Isocarboxazid and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Por que acontece
MAO inhibition potentiating sympathomimetic/pressor activity
O que fazer
Do not co-administer; wait at least 14 days after stopping the MAO inhibitor before using it.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenylephrine
- Phenelzine + Phenylephrine Contraindicada
- Phenylephrine + Tranylcypromine Contraindicada
- Bromocriptine + Phenylephrine Grave
- Cocaine + Phenylephrine Grave
- Dihydroergotamine intranasal + Phenylephrine Grave
- Dihydroergotamine + Phenylephrine Grave
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Isocarboxazid with Phenylephrine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, and phenylephrine is a direct alpha-1 agonist; with MAO inhibition pressor response is potentiated because MAO inhibition reduces catecholamine breakdown and sensitises tissues. Heart-rate and blood pressure rises, arrhythmia or a hypertensive crisis can result.
How serious is the interaction between Isocarboxazid and Phenylephrine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; wait at least 14 days after stopping the MAO inhibitor before using it.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Phenelzine, Tranylcypromine, Bromocriptine. The full list is on the Phenylephrine page.
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