Interações medicamentosas
Phenelzine + Phenylephrine
Gravidade: Contraindicada
Phenelzine and Phenylephrine: contraindicated interaction.
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Resumo
Phenelzine is an irreversible MAO inhibitor, which can greatly amplify the pressor response to sympathomimetics. A hypertensive crisis may occur.
O que esta interação significa em palavras simples
Phenelzine and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Por que acontece
Inhibition of MAO increases availability of norepinephrine and enhances the pressor response to phenylephrine.
O que fazer
Avoid systemic phenylephrine in patients taking MAO inhibitors, including for two weeks after stopping. Use a non-sympathomimetic decongestant alternative.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicada
- Phenylephrine + Tranylcypromine Contraindicada
- Bromocriptine + Phenylephrine Grave
- Cocaine + Phenylephrine Grave
- Dihydroergotamine intranasal + Phenylephrine Grave
- Dihydroergotamine + Phenylephrine Grave
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Phenelzine with Phenylephrine?
MediHelp rates the interaction as contraindicated. Phenelzine and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine is an irreversible MAO inhibitor, which can greatly amplify the pressor response to sympathomimetics. A hypertensive crisis may occur.
How serious is the interaction between Phenelzine and Phenylephrine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic phenylephrine in patients taking MAO inhibitors, including for two weeks after stopping. Use a non-sympathomimetic decongestant alternative.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Tranylcypromine, Bromocriptine. The full list is on the Phenylephrine page.
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