Interações medicamentosas
Cocaine + Phenylephrine
Gravidade: Grave
Cocaine and Phenylephrine: major interaction.
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Resumo
Cocaine combined with phenylephrine can cause additive vasoconstriction and pressor effects, increasing the risk of severe hypertension, myocardial ischemia and arrhythmia.
O que esta interação significa em palavras simples
Cocaine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Por que acontece
Additive sympathomimetic effects: cocaine reuptake blockade plus alpha-1 agonism.
O que fazer
Avoid additional vasoconstrictors where possible. If unavoidable, use the lowest dose with prolonged ECG and blood pressure monitoring.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cocaine
- Cocaine + Isocarboxazid Contraindicada
- Cocaine + Phenelzine Contraindicada
- Cocaine + Procarbazine Contraindicada
- Amitriptyline + Cocaine Grave
- Bisoprolol + Cocaine Grave
- Citalopram + Cocaine Grave
Outras interações de Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicada
- Phenelzine + Phenylephrine Contraindicada
- Phenylephrine + Tranylcypromine Contraindicada
- Bromocriptine + Phenylephrine Grave
- Dihydroergotamine intranasal + Phenylephrine Grave
- Dihydroergotamine + Phenylephrine Grave
Perguntas frequentes
Can I take Cocaine with Phenylephrine?
MediHelp rates the interaction as major. Cocaine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine combined with phenylephrine can cause additive vasoconstriction and pressor effects, increasing the risk of severe hypertension, myocardial ischemia and arrhythmia.
How serious is the interaction between Cocaine and Phenylephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid additional vasoconstrictors where possible. If unavoidable, use the lowest dose with prolonged ECG and blood pressure monitoring.
What other medicines interact with Cocaine?
MediHelp also lists interactions of Cocaine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Cocaine page.
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