Interações medicamentosas
Doxycycline + Magnesium sulphate
Gravidade: Moderada
Doxycycline and Magnesium sulphate: moderate interaction.
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Resumo
Oral magnesium salts bind tetracyclines in the gut and reduce their absorption, which can lead to subtherapeutic antibiotic levels and treatment failure. The interaction is relevant only when both are given orally.
O que esta interação significa em palavras simples
Doxycycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
Por que acontece
Chelation of doxycycline by divalent magnesium cations in the gastrointestinal tract, forming poorly absorbed complexes.
O que fazer
Give doxycycline at least 2 hours before or several hours after oral magnesium. Intravenous magnesium does not need separation.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Magnesium sulphate
- Amikacin + Magnesium sulphate Moderada
- Amphotericin b deoxycholate + Magnesium sulphate Moderada
- Atracurium + Magnesium sulphate Moderada
- Baloxavir marboxil + Magnesium sulphate Moderada
- Ciprofloxacin + Magnesium sulphate Moderada
- Cisatracurium + Magnesium sulphate Moderada
Outras interações de Doxycycline
- Acitretin + Doxycycline Contraindicada
- Aminolevulinic acid + Doxycycline Grave
- Cholera vaccine + Doxycycline Grave
- Doxycycline + Isotretinoin Grave
- Doxycycline + Methoxyflurane Grave
- Doxycycline + Microbiota Grave
Perguntas frequentes
Can I take Doxycycline with Magnesium sulphate?
MediHelp rates the interaction as moderate. Doxycycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium salts bind tetracyclines in the gut and reduce their absorption, which can lead to subtherapeutic antibiotic levels and treatment failure. The interaction is relevant only when both are given orally.
How serious is the interaction between Doxycycline and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give doxycycline at least 2 hours before or several hours after oral magnesium. Intravenous magnesium does not need separation.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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