Interações medicamentosas
Glycerol phenylbutyrate + Hydrocortisone
Gravidade: Moderada
Glycerol phenylbutyrate and Hydrocortisone: moderate interaction.
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Resumo
Corticosteroids promote protein catabolism, which can raise plasma ammonia. This opposes the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders and risks hyperammonemia.
O que esta interação significa em palavras simples
Glycerol phenylbutyrate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.
Por que acontece
Corticosteroid-induced protein breakdown increases nitrogen load and ammonia production, counteracting nitrogen scavenging.
O que fazer
Monitor plasma ammonia closely when starting, stopping or changing hydrocortisone dose. Adjust glycerol phenylbutyrate and dietary protein as advised by the metabolic team.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicada
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicada
- Hydrocortisone + Smallpox vaccine live Contraindicada
- Adenovirus types 4 and 7 live + Hydrocortisone Grave
- Aldesleukin + Hydrocortisone Grave
- Aspirin + Hydrocortisone Grave
Outras interações de Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Grave
- Glycerol phenylbutyrate + Sodium valproate Grave
- Glycerol phenylbutyrate + Valproic acid Grave
- Cyclosporin + Glycerol phenylbutyrate Moderada
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderada
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderada
Perguntas frequentes
Can I take Glycerol phenylbutyrate with Hydrocortisone?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism, which can raise plasma ammonia. This opposes the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders and risks hyperammonemia.
How serious is the interaction between Glycerol phenylbutyrate and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting, stopping or changing hydrocortisone dose. Adjust glycerol phenylbutyrate and dietary protein as advised by the metabolic team.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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