Interações medicamentosas
Imipramine + Pefloxacin
Gravidade: Moderada
Imipramine and Pefloxacin: moderate interaction.
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Resumo
Pefloxacin inhibits CYP1A2, one of the pathways metabolizing imipramine, so tricyclic levels may increase. Fluoroquinolones can also lower seizure threshold and prolong QT, adding to tricyclic toxicity.
O que esta interação significa em palavras simples
Imipramine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
Por que acontece
CYP1A2 inhibition reducing imipramine clearance, with additive seizure and QT effects.
O que fazer
Monitor for tricyclic adverse effects and ECG changes, and consider reducing imipramine dose or choosing a non-interacting antibiotic.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Imipramine
- Dronedarone + Imipramine Contraindicada
- Imipramine + Isocarboxazid Contraindicada
- Imipramine + Phenelzine Contraindicada
- Imipramine + Pimozide Contraindicada
- Imipramine + Rasagiline Contraindicada
- Imipramine + Safinamide Contraindicada
Outras interações de Pefloxacin
- Pefloxacin + Tizanidine Contraindicada
- Clozapine + Pefloxacin Grave
- Duloxetine + Pefloxacin Grave
- Pefloxacin + Theophylline Grave
- Asenapine + Pefloxacin Moderada
- Caffeine + Pefloxacin Moderada
Perguntas frequentes
Can I take Imipramine with Pefloxacin?
MediHelp rates the interaction as moderate. Imipramine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pefloxacin inhibits CYP1A2, one of the pathways metabolizing imipramine, so tricyclic levels may increase. Fluoroquinolones can also lower seizure threshold and prolong QT, adding to tricyclic toxicity.
How serious is the interaction between Imipramine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and ECG changes, and consider reducing imipramine dose or choosing a non-interacting antibiotic.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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