Interações medicamentosas
Ixekizumab + Phenytoin
Gravidade: Leve
Ixekizumab and Phenytoin: minor interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
O que esta interação significa em palavras simples
Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Por que acontece
Normalisation of cytokine-suppressed CYP450 enzyme expression after IL-17A blockade may alter phenytoin metabolism.
O que fazer
Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
O que perguntar ao farmacêutico
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Outras interações de Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicada
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Doravirine + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
Outras interações de Ixekizumab
Perguntas frequentes
Can I take Ixekizumab with Phenytoin?
MediHelp rates the interaction as minor. Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
How serious is the interaction between Ixekizumab and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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