Interações medicamentosas
Midazolam + Pheniramine
Gravidade: Moderada
Midazolam and Pheniramine: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Pheniramine is a first-generation sedating antihistamine, and combined with midazolam it can produce additive drowsiness, psychomotor impairment and, at higher doses, respiratory depression. Elderly patients are particularly vulnerable to confusion and falls.
O que esta interação significa em palavras simples
Midazolam and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Pheniramine belongs to Respiratory.
Por que acontece
Additive CNS depression from central H1 antagonism and GABA-A potentiation.
O que fazer
Reduce the midazolam dose, titrate carefully, and monitor sedation and respiratory rate; avoid in frail patients if alternatives exist.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Midazolam
- Atazanavir + Midazolam Contraindicada
- Cobicistat + Midazolam Contraindicada
- Darunavir + Midazolam Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicada
- Fosamprenavir + Midazolam Contraindicada
- Indinavir + Midazolam Contraindicada
Outras interações de Pheniramine
- Amisulpride + Pheniramine Moderada
- Asenapine + Pheniramine Moderada
- Brexpiprazole + Pheniramine Moderada
- Brivaracetam + Pheniramine Moderada
- Cariprazine + Pheniramine Moderada
- Fentanyl + Pheniramine Moderada
Perguntas frequentes
Can I take Midazolam with Pheniramine?
MediHelp rates the interaction as moderate. Midazolam and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a first-generation sedating antihistamine, and combined with midazolam it can produce additive drowsiness, psychomotor impairment and, at higher doses, respiratory depression. Elderly patients are particularly vulnerable to confusion and falls.
How serious is the interaction between Midazolam and Pheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the midazolam dose, titrate carefully, and monitor sedation and respiratory rate; avoid in frail patients if alternatives exist.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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