藥品參考
Avelumab
Avelumab is a medicine in the class oncology. It is used for renal cell carcinoma.
- 藥物類別: Oncology
- 用途: renal cell carcinoma
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01FF04
- 常見劑型
- 注射劑
- 常見規格
- 20 mg/ml
- 已知交互作用
- 5 (中度: 4 · 輕微: 1)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Human IgG1 monoclonal antibody against PD-L1. It blocks PD-L1 interaction with PD-1 and B7.1 receptors, removing suppression of cytotoxic CD8+ T-cells and restoring anti-tumour T-cell responses. It also induces NK cell-mediated tumour cell lysis via ADCC.
成人常用劑量（仿單摘要）
Monotherapy (MCC; first-line maintenance UC): 800 mg IV over 60 minutes every 2 weeks until disease progression or unacceptable toxicity
懷孕與哺乳
- 懷孕
- Unsafe Limited data; based on mechanism it could cause foetal harm including abortion or stillbirth. Not recommended during pregnancy unless the woman's condition requires treatment.
- 哺乳
- Unsafe Unknown if excreted in human milk; advised not to breast-feed during treatment and for at least 1 month after the last dose.
已通報的副作用
- Fatigue
- Nausea
- Diarrhoea
- Constipation
- Decreased appetite
- Infusion-related reactions
禁忌症
- Hypersensitivity to the active substance or to any excipient
哪些人需要特別留意
- Infusion-related reactions can be severe; monitor for pyrexia, chills, flushing, hypotension, dyspnoea, wheezing, back pain, abdominal pain and urticaria.
- Immune-mediated adverse reactions (pneumonitis, hepatitis, colitis, pancreatitis, myocarditis, endocrinopathies, nephritis) may be severe or fatal; monitor, withhold and give corticosteroids according to severity.
- With axitinib, hepatotoxicity occurs with higher frequency of Grade 3 and 4 ALT/AST elevation; monitor liver function more frequently than with monotherapy.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (5)
- Avelumab + Cefadroxil Moderate
- Avelumab + Cefalexin Moderate
- Avelumab + Piperacillin Moderate
- Avelumab + Piperacillin-tazobactam Moderate
- Avelumab + Penicillin g Minor
同類別的其他藥品
常見問題
What is Avelumab used for?
Avelumab is a medicine in the class oncology. It is used for Renal cell carcinoma.
What side effects have been reported with Avelumab?
Fatigue, Nausea, Diarrhoea, Constipation, Decreased appetite, Infusion-related reactions.
Can Avelumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Limited data; based on mechanism it could cause foetal harm including abortion or stillbirth. Not recommended during pregnancy unless the woman's condition requires treatment. Breastfeeding: Unsafe. Unknown if excreted in human milk; advised not to breast-feed during treatment and for at least 1 month after the last dose.
What does Avelumab interact with?
MediHelp lists 5 known interactions for Avelumab. Moderate: 4 · Minor: 1. The most serious include Cefadroxil, Cefalexin, Piperacillin.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
