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Blinatumomab

Blinatumomab is a medicine in the class oncology. It is used for acute lymphocytic leukemia.

最後更新 來源: US FDA label

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別
Oncology
ATC 代碼
L01FX07
常見規格
35 mcg
已知交互作用
14 (中度: 13 · 輕微: 1)
商品名
2
國家與市場
2

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

用途

作用方式

Bispecific CD19-directed CD3 T-cell engager that connects CD3 on T-cells with CD19 on benign and malignant B-cells, activating T-cells and causing redirected lysis of CD19+ cells.

成人常用劑量（仿單摘要）

MRD-positive B-cell precursor ALL: patients 45 kg or more 28 mcg/day by continuous IV infusion on Days 1-28 of each 42-day cycle (14-day treatment-free interval); 1 induction cycle then up to 3 consolidation cycles

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕
Unsafe May cause fetal harm based on mechanism; no human data. Can cause B-cell lymphocytopenia in exposed infants. Verify pregnancy status before treatment.
哺乳
Unsafe Advise not to breastfeed during treatment and for 48 hours after the last dose.

已通報的副作用

  • Pyrexia
  • Infusion-related reactions
  • Headache
  • Infection
  • Musculoskeletal pain
  • Neutropenia

黑框警語

  • Cytokine release syndrome, which may be life-threatening or fatal, occurred. Interrupt or discontinue and treat with corticosteroids as recommended.

禁忌症

  • Known hypersensitivity to blinatumomab or any component of the formulation.

哪些人需要特別留意

  • CRS: monitor; interrupt for severe CRS and discontinue permanently for life-threatening CRS.
  • Neurological toxicities including ICANS; consider seizure prophylaxis in Down syndrome patients.
  • Serious infections occurred in approximately 25% of patients; consider prophylactic antibiotics and monitor.

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (14)

All 14 interactions, with severity and what to do

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解鎖完整頁面

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  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
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同類別的其他藥品

常見問題

What is Blinatumomab used for?

Blinatumomab is a medicine in the class oncology. It is used for Acute lymphocytic leukemia.

What side effects have been reported with Blinatumomab?

Pyrexia, Infusion-related reactions, Headache, Infection, Musculoskeletal pain, Neutropenia. Serious warning: Cytokine release syndrome, which may be life-threatening or fatal, occurred.

Can Blinatumomab be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. May cause fetal harm based on mechanism; no human data. Can cause B-cell lymphocytopenia in exposed infants. Verify pregnancy status before treatment. Breastfeeding: Unsafe. Advise not to breastfeed during treatment and for 48 hours after the last dose.

What does Blinatumomab interact with?

MediHelp lists 14 known interactions for Blinatumomab. Moderate: 13 · Minor: 1. The most serious include Carbamazepine, Cyclosporin, Ethosuximide.

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