藥物交互作用
Fostemsavir + Pimozide
嚴重程度: 嚴重
Fostemsavir and Pimozide: major interaction.
最後更新
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摘要
Fostemsavir has caused QT prolongation at supratherapeutic doses, and pimozide is a strongly QT-prolonging drug with a narrow margin of safety. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.
用白話說明這項交互作用的意義
Fostemsavir and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fostemsavir belongs to Anti Virals; Pimozide belongs to Central Nervous System.
為什麼會發生
Additive QT-interval prolongation through cardiac repolarization effects.
處置方式
Obtain a baseline ECG and monitor QTc and electrolytes if the combination cannot be avoided. Correct potassium and magnesium abnormalities, and choose an alternative if QTc becomes markedly prolonged.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pimozide 的其他交互作用
Fostemsavir 的其他交互作用
常見問題
Can I take Fostemsavir with Pimozide?
MediHelp rates the interaction as major. Fostemsavir and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fostemsavir has caused QT prolongation at supratherapeutic doses, and pimozide is a strongly QT-prolonging drug with a narrow margin of safety. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Fostemsavir and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes if the combination cannot be avoided. Correct potassium and magnesium abnormalities, and choose an alternative if QTc becomes markedly prolonged.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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