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藥物交互作用

Fostemsavir + Sofosbuvir-velpatasvir-voxilaprevir

嚴重程度: 嚴重

Fostemsavir and Sofosbuvir-velpatasvir-voxilaprevir: major interaction.

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本頁的臨床內容僅提供英文版。

摘要

Fostemsavir's active metabolite temsavir inhibits OATP1B1/1B3 and BCRP, which raises voxilaprevir exposure. This may increase the risk of ALT elevations.

用白話說明這項交互作用的意義

Fostemsavir and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fostemsavir belongs to Anti Virals; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.

證據等級: Moderate

為什麼會發生

Temsavir inhibits OATP1B1/1B3 and BCRP, which reduces hepatic uptake and efflux of voxilaprevir.

處置方式

Use an alternative HCV regimen if possible. If used together, monitor ALT and liver function.

可向藥師詢問的問題

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Fostemsavir 與 Sofosbuvir-velpatasvir-voxilaprevir 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Fostemsavir with Sofosbuvir-velpatasvir-voxilaprevir?

MediHelp rates the interaction as major. Fostemsavir and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fostemsavir's active metabolite temsavir inhibits OATP1B1/1B3 and BCRP, which raises voxilaprevir exposure. This may increase the risk of ALT elevations.

How serious is the interaction between Fostemsavir and Sofosbuvir-velpatasvir-voxilaprevir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative HCV regimen if possible. If used together, monitor ALT and liver function.

What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?

MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.

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