藥品參考
Methohexital
Methohexital is a medicine in the class central nervous system. It is used for general anesthesia.
- 藥物類別: Central Nervous System
- 用途: general anesthesia
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- 常見劑型
- 注射劑
- 常見規格
- 500 mg
- 已知交互作用
- 118 (嚴重: 27 · 中度: 83 · 輕微: 8)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Methohexital is a sulfur-free barbiturate anesthetic. After intravenous administration it is rapidly taken up by the brain (within 30 seconds) and rapidly induces sleep. With single doses, the rate of redistribution determines the duration of effect. It provides little analgesia.
成人常用劑量（仿單摘要）
Induction of anesthesia: 1% solution IV at about 1 mL/5 seconds; usual dose 1 to 1.5 mg/kg (range 50 to 120 mg or more, averages about 70 mg); provides anesthesia for 5 to 7 minutes
懷孕與哺乳
- 懷孕
- Unknown No adequate human studies; no developmental effects in rats and rabbits. FDA warns that lengthy or repeated general anaesthesia in the 3rd trimester may affect the developing brain (animal data). Use for needed anaesthesia or ECT at the usual dose.
- 哺乳
- Safe Amounts in milk are very small. US label: use with caution. LactMed: no waiting period is needed after a single dose; breastfeed as soon as the mother is alert enough. When several anaesthetic drugs are used, follow the most restrictive one.
已通報的副作用
- Hypotension
- Tachycardia
- Respiratory depression including apnea
- Laryngospasm
- Hiccups
- Skeletal muscle twitching
黑框警語
- Use only in hospital or ambulatory care settings with continuous monitoring of respiratory and cardiac function. Resuscitative drugs, age- and size-appropriate airway equipment and trained personnel must be immediately available. Deeply sedated patients need a designated individual other than the proceduralist to monitor continuously.
禁忌症
- Patients in whom general anesthesia is contraindicated
- Latent or manifest porphyria
- Known hypersensitivity to barbiturates
哪些人需要特別留意
- Laryngospasm, apnea/hypoventilation and cardiorespiratory arrest may occur; maintain airway and ventilation
- Seizures may be elicited in patients with a history of convulsive activity, especially partial seizure disorders
- Unintended intra-arterial injection may cause thrombosis, necrosis and gangrene; use 1% concentration and confirm venous placement
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (118)
- Alprazolam + Methohexital Major
- Amobarbital + Methohexital Major
- Buprenorphine + Methohexital Major
- Chlordiazepoxide + Methohexital Major
- Chlordiazepoxide-clidinium + Methohexital Major
- Clemastine + Methohexital Major
- Clorazepate + Methohexital Major
- Clozapine + Methohexital Major
- Codeine + Methohexital Major
- Esketamine + Methohexital Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Methohexital 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Methohexital used for?
Methohexital is a medicine in the class central nervous system. It is used for General anesthesia, General anesthesia adjunct.
What side effects have been reported with Methohexital?
Hypotension, Tachycardia, Respiratory depression including apnea, Laryngospasm, Hiccups, Skeletal muscle twitching. Serious warning: Use only in hospital or ambulatory care settings with continuous monitoring of respiratory and cardiac function.
Can Methohexital be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human studies; no developmental effects in rats and rabbits. FDA warns that lengthy or repeated general anaesthesia in the 3rd trimester may affect the developing brain (animal data). Use for needed anaesthesia or ECT at the usual dose. Breastfeeding: Safe. Amounts in milk are very small. US label: use with caution. LactMed: no waiting period is needed after a single dose; breastfeed as soon as the mother is alert enough. When several anaesthetic drugs are used, follow the most restrictive one.
What does Methohexital interact with?
MediHelp lists 118 known interactions for Methohexital. Major: 27 · Moderate: 83 · Minor: 8. The most serious include Alprazolam, Amobarbital, Buprenorphine.
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