藥物交互作用
Clorazepate + Methohexital
嚴重程度: 嚴重
Clorazepate and Methohexital: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Methohexital is a barbiturate anesthetic and with a benzodiazepine can produce additive sedation and respiratory depression. Hypotension and airway compromise may occur.
用白話說明這項交互作用的意義
Clorazepate and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clorazepate belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
為什麼會發生
Additive GABA-A mediated CNS and respiratory depression.
處置方式
Use in monitored settings, titrating methohexital to effect with lower doses. Ensure airway and ventilation support are available.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clorazepate 的其他交互作用
Methohexital 的其他交互作用
常見問題
Can I take Clorazepate with Methohexital?
MediHelp rates the interaction as major. Clorazepate and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic and with a benzodiazepine can produce additive sedation and respiratory depression. Hypotension and airway compromise may occur.
How serious is the interaction between Clorazepate and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use in monitored settings, titrating methohexital to effect with lower doses. Ensure airway and ventilation support are available.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
