藥物交互作用
Chlordiazepoxide-clidinium + Methohexital
嚴重程度: 嚴重
Chlordiazepoxide-clidinium and Methohexital: major interaction.
最後更新
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摘要
Methohexital is a barbiturate anesthetic; with chlordiazepoxide it produces additive sedation and respiratory depression. Risks include hypoventilation and hypotension during procedural use.
用白話說明這項交互作用的意義
Chlordiazepoxide-clidinium and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Methohexital belongs to Central Nervous System.
為什麼會發生
Additive GABA-A mediated CNS and respiratory depression.
處置方式
Titrate methohexital to effect with reduced doses, and monitor airway, oxygenation and blood pressure continuously.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide-clidinium 的其他交互作用
Methohexital 的其他交互作用
常見問題
Can I take Chlordiazepoxide-clidinium with Methohexital?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic; with chlordiazepoxide it produces additive sedation and respiratory depression. Risks include hypoventilation and hypotension during procedural use.
How serious is the interaction between Chlordiazepoxide-clidinium and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital to effect with reduced doses, and monitor airway, oxygenation and blood pressure continuously.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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