藥品參考
Neratinib
Neratinib is a medicine in the class oncology. It is used for breast cancer.
- 藥物類別: Oncology
- 用途: breast cancer
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01EH02
- 常見劑型
- 錠劑
- 常見規格
- 40 mg
- 已知交互作用
- 59 (嚴重: 40 · 中度: 14 · 輕微: 5)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Intracellular kinase inhibitor that irreversibly binds EGFR, HER2 and HER4; reduces EGFR and HER2 autophosphorylation and downstream MAPK and AKT signaling.
成人常用劑量（仿單摘要）
Extended adjuvant treatment of early-stage HER2-positive breast cancer: 240 mg (six tablets) orally once daily with food, continuously until disease recurrence or for up to one year.
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: no human data; in rabbits it caused abortion, embryo-fetal death and fetal abnormalities at exposures below those in patients. Test for pregnancy before starting; use effective contraception during treatment and for at least 1 month after (men: 3 months).
- 哺乳
- Unsafe No human milk data. LactMed: over 99% protein bound, so milk levels are likely low. US label: do not breastfeed during treatment and for at least 1 month after the last dose.
已通報的副作用
- Diarrhea
- Nausea
- Abdominal pain
- Fatigue
- Vomiting
- Rash
禁忌症
- None.
哪些人需要特別留意
- Severe diarrhea with dehydration, hypotension and renal failure can occur; use loperamide prophylaxis or dose escalation, monitor and treat, interrupt and reduce dose as needed.
- Hepatotoxicity: measure total bilirubin, AST, ALT and alkaline phosphatase before treatment, monthly for 3 months, then every 3 months and as clinically indicated.
- Embryo-fetal toxicity: can cause fetal harm; use effective contraception.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (59)
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
- Cimetidine + Neratinib Major
- Clarithromycin + Neratinib Major
- Colchicine + Neratinib Major
- Crizotinib + Neratinib Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Neratinib 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Neratinib used for?
Neratinib is a medicine in the class oncology. It is used for Breast cancer.
What side effects have been reported with Neratinib?
Diarrhea, Nausea, Abdominal pain, Fatigue, Vomiting, Rash.
Can Neratinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: no human data; in rabbits it caused abortion, embryo-fetal death and fetal abnormalities at exposures below those in patients. Test for pregnancy before starting; use effective contraception during treatment and for at least 1 month after (men: 3 months). Breastfeeding: Unsafe. No human milk data. LactMed: over 99% protein bound, so milk levels are likely low. US label: do not breastfeed during treatment and for at least 1 month after the last dose.
What does Neratinib interact with?
MediHelp lists 59 known interactions for Neratinib. Major: 40 · Moderate: 14 · Minor: 5. The most serious include Amiodarone, Amobarbital, Aprepitant.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
