藥物交互作用
Clarithromycin + Neratinib
嚴重程度: 嚴重
Clarithromycin and Neratinib: major interaction.
最後更新
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摘要
Clarithromycin increases neratinib exposure, raising the risk of diarrhea, hepatotoxicity and other adverse effects.
用白話說明這項交互作用的意義
Clarithromycin and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Neratinib belongs to Oncology.
為什麼會發生
Strong CYP3A4 (and P-gp) inhibition reduces neratinib clearance.
處置方式
Avoid concurrent use and select an alternative antibiotic. If unavoidable, monitor closely for diarrhea and liver toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clarithromycin 的其他交互作用
Neratinib 的其他交互作用
常見問題
Can I take Clarithromycin with Neratinib?
MediHelp rates the interaction as major. Clarithromycin and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin increases neratinib exposure, raising the risk of diarrhea, hepatotoxicity and other adverse effects.
How serious is the interaction between Clarithromycin and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select an alternative antibiotic. If unavoidable, monitor closely for diarrhea and liver toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
