藥物交互作用
Aprepitant + Neratinib
嚴重程度: 嚴重
Aprepitant and Neratinib: major interaction.
最後更新
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摘要
Aprepitant may raise neratinib concentrations via CYP3A4 inhibition. This may worsen neratinib toxicity, notably severe diarrhea and liver injury.
用白話說明這項交互作用的意義
Aprepitant and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Neratinib belongs to Oncology.
為什麼會發生
Aprepitant inhibits CYP3A4, the main route of neratinib metabolism.
處置方式
Avoid moderate CYP3A4 inhibitors with neratinib and select an alternative antiemetic. If unavoidable, monitor for diarrhea and liver function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Aprepitant 的其他交互作用
Neratinib 的其他交互作用
常見問題
Can I take Aprepitant with Neratinib?
MediHelp rates the interaction as major. Aprepitant and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant may raise neratinib concentrations via CYP3A4 inhibition. This may worsen neratinib toxicity, notably severe diarrhea and liver injury.
How serious is the interaction between Aprepitant and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid moderate CYP3A4 inhibitors with neratinib and select an alternative antiemetic. If unavoidable, monitor for diarrhea and liver function.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
