藥物交互作用
Crizotinib + Neratinib
嚴重程度: 嚴重
Crizotinib and Neratinib: major interaction.
最後更新
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摘要
Neratinib is mainly metabolized by CYP3A4, and crizotinib may increase its exposure. This can worsen diarrhea, hepatotoxicity and other adverse effects.
用白話說明這項交互作用的意義
Crizotinib and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Neratinib belongs to Oncology.
為什麼會發生
Crizotinib inhibits CYP3A4 metabolism of neratinib.
處置方式
Avoid the combination where possible. If used, monitor for severe diarrhea and liver enzyme elevation, with antidiarrheal prophylaxis.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Crizotinib 的其他交互作用
Neratinib 的其他交互作用
常見問題
Can I take Crizotinib with Neratinib?
MediHelp rates the interaction as major. Crizotinib and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Neratinib is mainly metabolized by CYP3A4, and crizotinib may increase its exposure. This can worsen diarrhea, hepatotoxicity and other adverse effects.
How serious is the interaction between Crizotinib and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor for severe diarrhea and liver enzyme elevation, with antidiarrheal prophylaxis.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
