藥物交互作用
Cimetidine + Neratinib
嚴重程度: 嚴重
Cimetidine and Neratinib: major interaction.
最後更新
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摘要
Neratinib solubility falls as pH rises, and H2 antagonists reduce its absorption. This may reduce efficacy in breast cancer treatment.
用白話說明這項交互作用的意義
Cimetidine and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Neratinib belongs to Oncology.
為什麼會發生
Cimetidine raises gastric pH, decreasing neratinib dissolution and absorption.
處置方式
Avoid H2 antagonists if possible; if needed, take neratinib at least 2 hours before the next H2 antagonist dose and at least 10 hours after the previous one.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cimetidine 的其他交互作用
Neratinib 的其他交互作用
常見問題
Can I take Cimetidine with Neratinib?
MediHelp rates the interaction as major. Cimetidine and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Neratinib solubility falls as pH rises, and H2 antagonists reduce its absorption. This may reduce efficacy in breast cancer treatment.
How serious is the interaction between Cimetidine and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 antagonists if possible; if needed, take neratinib at least 2 hours before the next H2 antagonist dose and at least 10 hours after the previous one.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
