藥品參考
Orlistat
Orlistat is a medicine in the class miscellaneous. It is used for obesity.
- 藥物類別: Miscellaneous
- 用途: obesity
最後更新
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- A08AB01
- 常見劑型
- 膠囊
- 常見規格
- 120 mg, 60 mg
- 已知交互作用
- 70 (嚴重: 3 · 中度: 44 · 輕微: 23)
- 商品名
- 25
- 國家與市場
- 5
用途
作用方式
Inhibits gastric and pancreatic lipases, prevents triglyceride hydrolysis resulting in decreased absorption of dietary fats
成人常用劑量（仿單摘要）
(Xenical): 120 mg PO q8hr with each fat-containing meal (during or up to 1 hr after the meal), doses >120 mg TID show no additional benefit
懷孕與哺乳
- 懷孕
- Unknown Not for use in pregnancy: weight loss offers no benefit in pregnancy and may harm the fetus (US label contraindication). No embryo toxicity or malformations in animals at high doses. Stop if pregnancy occurs; the EU label advises caution.
- 哺乳
- Safe Very little is absorbed; a small amount was found in one woman's milk. EU label contraindicates breastfeeding (no data); US label: caution. LactMed: unlikely to affect the infant; the mother should take a multivitamin at bedtime because it lowers fat-soluble vitamin absorption.
已通報的副作用
- Flatulence
- Oily spotting
- Fatty/oily stool
- Increased defecation
哪些人需要特別留意
- Daily fat intake (30% of calories), carbohydrate, and protein should be evenly distributed over 3 main meals
- Postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure with some cases resulting in liver transplant or death
- Some patients may develop increased levels of urinary oxalate following treatment; cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure reported
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (70)
- Cyclosporin + Orlistat Major
- Cyclosporine + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
- Clobazam + Orlistat Moderate
- Clonazepam + Orlistat Moderate
- Clorazepate + Orlistat Moderate
常見問題
What is Orlistat used for?
Orlistat is a medicine in the class miscellaneous. It is used for Obesity.
What side effects have been reported with Orlistat?
Flatulence, Oily spotting, Fatty/oily stool, Increased defecation.
Can Orlistat be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Not for use in pregnancy: weight loss offers no benefit in pregnancy and may harm the fetus (US label contraindication). No embryo toxicity or malformations in animals at high doses. Stop if pregnancy occurs; the EU label advises caution. Breastfeeding: Safe. Very little is absorbed; a small amount was found in one woman's milk. EU label contraindicates breastfeeding (no data); US label: caution. LactMed: unlikely to affect the infant; the mother should take a multivitamin at bedtime because it lowers fat-soluble vitamin absorption.
What does Orlistat interact with?
MediHelp lists 70 known interactions for Orlistat. Major: 3 · Moderate: 44 · Minor: 23. The most serious include Cyclosporin, Cyclosporine, Triheptanoin.
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