藥物交互作用
Amiodarone + Orlistat
嚴重程度: 中度
Amiodarone and Orlistat: moderate interaction.
最後更新
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摘要
Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.
用白話說明這項交互作用的意義
Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Orlistat belongs to Miscellaneous.
為什麼會發生
Reduced intestinal absorption of lipophilic amiodarone due to lipase inhibition and reduced fat availability.
處置方式
Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amiodarone 的其他交互作用
Orlistat 的其他交互作用
常見問題
Can I take Amiodarone with Orlistat?
MediHelp rates the interaction as moderate. Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.
How serious is the interaction between Amiodarone and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
