藥物交互作用
Cyclosporin + Orlistat
嚴重程度: 嚴重
Cyclosporin and Orlistat: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Orlistat can lower cyclosporine absorption and cause subtherapeutic levels, with reported risk of transplant rejection. The effect is unpredictable between patients.
用白話說明這項交互作用的意義
Cyclosporin and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Orlistat belongs to Miscellaneous.
為什麼會發生
Orlistat reduces gastrointestinal fat absorption, impairing absorption of lipophilic cyclosporine.
處置方式
Avoid coadministration if possible. If used, monitor cyclosporine trough concentrations closely and adjust dose, and give cyclosporine at least 3 hours apart from orlistat.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cyclosporin 的其他交互作用
Orlistat 的其他交互作用
常見問題
Can I take Cyclosporin with Orlistat?
MediHelp rates the interaction as major. Cyclosporin and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orlistat can lower cyclosporine absorption and cause subtherapeutic levels, with reported risk of transplant rejection. The effect is unpredictable between patients.
How serious is the interaction between Cyclosporin and Orlistat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration if possible. If used, monitor cyclosporine trough concentrations closely and adjust dose, and give cyclosporine at least 3 hours apart from orlistat.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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