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Zoledronic acid

Zoledronic acid is a medicine in the class musculoskeletal. It is used for glucocorticoid-induced osteoporosis.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別
Musculoskeletal
ATC 代碼
M05BA08
常見劑型
注射劑, 輸注液
常見規格
4 mg/5 ml, 5 mg/100 ml, 4 mg
已知交互作用
19 (中度: 13 · 輕微: 6)
商品名
37
國家與市場
5

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

用途

作用方式

Bisphosphonate; inhibits bone resorption via actions on osteoclast activity, leading to indirect increase in bone density

成人常用劑量（仿單摘要）

Hypercalcemia of Malignancy (Zometa): No more than 4 mg IV (infused over >15 minutes) once; may be repeated in 7 days

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕
Unsafe No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised.
哺乳
Unknown No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.

已通報的副作用

  • Fatigue
  • Vomiting
  • Nausea
  • Constipation
  • Anemia
  • Bone pain

禁忌症

  • Pregnancy
  • All indications: Hypersensitivity, including rare cases of urticaria, angioedema, and anaphylactic reaction or shock
  • Nononcologic uses: Hypocalcemia, severe renal impairment (CrCl <35 mL/min or evidence of acute renal impairment)

哪些人需要特別留意

  • Infuse over ≥15 minutes; faster infusion increases renal toxicity
  • Increased risk of osteonecrosis of jaw (advise patients against dental work); reported predominantly in cancer patients treated with IV bisphosphonates
  • Risk of osteonecrosis of the jaw may increase with duration of exposure to bisphosphonates

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (19)

All 19 interactions, with severity and what to do

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解鎖完整頁面

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  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
  • IV preparation and dilution
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同類別的其他藥品

相關快速閱讀

常見問題

What is Zoledronic acid used for?

Zoledronic acid is a medicine in the class musculoskeletal. It is used for Glucocorticoid-induced osteoporosis, Hypercalcemia of malignancy, Osteoporosis, Paget's disease.

What side effects have been reported with Zoledronic acid?

Fatigue, Vomiting, Nausea, Constipation, Anemia, Bone pain.

Can Zoledronic acid be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised. Breastfeeding: Unknown. No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.

What does Zoledronic acid interact with?

MediHelp lists 19 known interactions for Zoledronic acid. Moderate: 13 · Minor: 6. The most serious include Amikacin, Bumetanide, Dichlorphenamide.

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