藥品參考
Pasireotide
Pasireotide is a medicine in the class endocrine. It is used for cushing syndrome.
- 藥物類別: Endocrine
- 用途: cushing syndrome
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Endocrine
- ATC 代碼
- H01CB05
- 常見劑型
- 注射劑
- 常見規格
- 20 mg
- 已知交互作用
- 125 (禁忌併用: 2 · 嚴重: 44 · 中度: 78 · 輕微: 1)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Injectable cyclohexapeptide somatostatin analogue that binds and activates somatostatin receptors (notably SSTR5, over-expressed in corticotroph tumors), inhibiting ACTH secretion and thereby decreasing cortisol secretion.
成人常用劑量（仿單摘要）
Cushing's disease: initial 0.6 mg or 0.9 mg subcutaneously twice a day; range 0.3 mg to 0.9 mg twice a day; titrate to response and tolerability
懷孕與哺乳
- 懷孕
- Unknown Limited human data. In rabbits it caused developmental delay at doses below human exposure without maternal toxicity; in rats, malrotated limbs at very high doses. EU label: not recommended in pregnancy; women may become fertile again as cortisol or GH falls, so use contraception.
- 哺乳
- Unknown No human milk data; passes into rat milk. EU label: stop breastfeeding during treatment; US label: weigh benefits. LactMed: a large peptide, likely poorly excreted and digested by the infant, but an alternate drug is preferred.
已通報的副作用
- Diarrhea
- Nausea
- Hyperglycemia
- Cholelithiasis
- Headache
- Abdominal pain
禁忌症
- None.
哪些人需要特別留意
- Hypocortisolism may occur; monitor, and consider dose reduction or interruption and temporary glucocorticoid replacement.
- Hyperglycemia and diabetes: monitor glycemia weekly for first two to three months and after dose increases; optimize antidiabetic therapy before starting.
- Bradycardia and QT prolongation: use caution in at-risk patients; baseline ECG recommended; correct hypokalemia and hypomagnesemia.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (125)
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
- Asenapine + Pasireotide Major
- Azithromycin + Pasireotide Major
- Citalopram + Pasireotide Major
- Clarithromycin + Pasireotide Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Pasireotide 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Pasireotide used for?
Pasireotide is a medicine in the class endocrine. It is used for Cushing syndrome.
What side effects have been reported with Pasireotide?
Diarrhea, Nausea, Hyperglycemia, Cholelithiasis, Headache, Abdominal pain.
Can Pasireotide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. In rabbits it caused developmental delay at doses below human exposure without maternal toxicity; in rats, malrotated limbs at very high doses. EU label: not recommended in pregnancy; women may become fertile again as cortisol or GH falls, so use contraception. Breastfeeding: Unknown. No human milk data; passes into rat milk. EU label: stop breastfeeding during treatment; US label: weigh benefits. LactMed: a large peptide, likely poorly excreted and digested by the infant, but an alternate drug is preferred.
What does Pasireotide interact with?
MediHelp lists 125 known interactions for Pasireotide. Contraindicated: 2 · Major: 44 · Moderate: 78 · Minor: 1. The most serious include Dronedarone, Pimozide, Amiodarone.
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