藥物交互作用
Clarithromycin + Pasireotide
嚴重程度: 嚴重
Clarithromycin and Pasireotide: major interaction.
最後更新
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摘要
Both drugs can prolong the QT interval, and pasireotide also causes bradycardia. Together they may increase the risk of torsades de pointes, particularly with electrolyte disturbance or heart disease.
用白話說明這項交互作用的意義
Clarithromycin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Pasireotide belongs to Endocrine.
為什麼會發生
Additive QT prolongation, with pasireotide-induced bradycardia adding to the arrhythmic risk.
處置方式
Check ECG and electrolytes at baseline and correct potassium and magnesium deficits. Monitor QTc during co-therapy, or choose a non-QT-prolonging antibiotic.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clarithromycin 的其他交互作用
Pasireotide 的其他交互作用
常見問題
Can I take Clarithromycin with Pasireotide?
MediHelp rates the interaction as major. Clarithromycin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and pasireotide also causes bradycardia. Together they may increase the risk of torsades de pointes, particularly with electrolyte disturbance or heart disease.
How serious is the interaction between Clarithromycin and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and correct potassium and magnesium deficits. Monitor QTc during co-therapy, or choose a non-QT-prolonging antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
