藥物交互作用
Ketoconazole + Tolvaptan
嚴重程度: 禁忌併用
Ketoconazole and Tolvaptan: contraindicated interaction.
最後更新
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摘要
Ketoconazole greatly increases tolvaptan exposure. This can cause excessively rapid aquaresis, dehydration, hypernatremia and osmotic demyelination risk from overly fast sodium correction.
用白話說明這項交互作用的意義
Ketoconazole and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Tolvaptan belongs to Endocrine.
為什麼會發生
Strong CYP3A4 inhibition markedly decreases tolvaptan metabolism.
處置方式
Avoid the combination; strong CYP3A4 inhibitors are contraindicated with tolvaptan. Use an alternative antifungal, or hold tolvaptan during treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ketoconazole 的其他交互作用
Tolvaptan 的其他交互作用
常見問題
Can I take Ketoconazole with Tolvaptan?
MediHelp rates the interaction as contraindicated. Ketoconazole and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole greatly increases tolvaptan exposure. This can cause excessively rapid aquaresis, dehydration, hypernatremia and osmotic demyelination risk from overly fast sodium correction.
How serious is the interaction between Ketoconazole and Tolvaptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; strong CYP3A4 inhibitors are contraindicated with tolvaptan. Use an alternative antifungal, or hold tolvaptan during treatment.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
