藥品參考
Venetoclax
Venetoclax is a medicine in the class miscellaneous. It is used for chronic lymphocytic leukemia.
- 藥物類別: Miscellaneous
- 用途: chronic lymphocytic leukemia
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- L01XX52
- 常見劑型
- 錠劑
- 常見規格
- 10 mg
- 已知交互作用
- 68 (禁忌併用: 5 · 嚴重: 37 · 中度: 23 · 輕微: 3)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Selective, orally bioavailable small-molecule inhibitor of BCL-2, an anti-apoptotic protein. It binds BCL-2 directly, displacing pro-apoptotic proteins like BIM, which restores apoptosis through mitochondrial outer membrane permeabilization and caspase activation.
成人常用劑量（仿單摘要）
CLL/SLL: 5-week ramp-up orally once daily (Week 1 20 mg, Week 2 50 mg, Week 3 100 mg, Week 4 200 mg), then 400 mg once daily from Week 5 and beyond
懷孕與哺乳
- 懷孕
- Unsafe May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose.
- 哺乳
- Unsafe No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.
已通報的副作用
- Neutropenia
- Thrombocytopenia
- Anemia
- Diarrhea
- Nausea
- Fatigue
禁忌症
- Concomitant use with strong CYP3A inhibitors at initiation and during the ramp-up phase in patients with CLL/SLL, due to increased TLS risk
哪些人需要特別留意
- Tumor lysis syndrome, including fatal events and renal failure requiring dialysis; assess risk, give hydration and anti-hyperuricemics, and monitor blood chemistries
- Neutropenia: monitor complete blood counts throughout treatment and consider supportive measures
- Fatal and serious infections such as pneumonia and sepsis; withhold for Grade 3 and 4 infection until resolution
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (68)
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
- Apalutamide + Venetoclax Major
- Aprepitant + Venetoclax Major
- Armodafinil + Venetoclax Major
- Bosentan + Venetoclax Major
常見問題
What is Venetoclax used for?
Venetoclax is a medicine in the class miscellaneous. It is used for Chronic lymphocytic leukemia, Leukemia.
What side effects have been reported with Venetoclax?
Neutropenia, Thrombocytopenia, Anemia, Diarrhea, Nausea, Fatigue.
Can Venetoclax be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose. Breastfeeding: Unsafe. No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.
What does Venetoclax interact with?
MediHelp lists 68 known interactions for Venetoclax. Contraindicated: 5 · Major: 37 · Moderate: 23 · Minor: 3. The most serious include Clarithromycin, Itraconazole, Ketoconazole.
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