藥物交互作用
Ketoconazole + Venetoclax
嚴重程度: 禁忌併用
Ketoconazole and Venetoclax: contraindicated interaction.
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摘要
Ketoconazole markedly raises venetoclax exposure, increasing the risk of tumor lysis syndrome and neutropenia. It is contraindicated during the initial ramp-up phase.
用白話說明這項交互作用的意義
Ketoconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Venetoclax belongs to Miscellaneous.
為什麼會發生
Strong CYP3A4 inhibition (and P-gp inhibition) reduces venetoclax clearance.
處置方式
Avoid during ramp-up. After ramp-up, reduce the venetoclax dose by at least 75% and monitor for toxicity.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ketoconazole 的其他交互作用
Venetoclax 的其他交互作用
常見問題
Can I take Ketoconazole with Venetoclax?
MediHelp rates the interaction as contraindicated. Ketoconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly raises venetoclax exposure, increasing the risk of tumor lysis syndrome and neutropenia. It is contraindicated during the initial ramp-up phase.
How serious is the interaction between Ketoconazole and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during ramp-up. After ramp-up, reduce the venetoclax dose by at least 75% and monitor for toxicity.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
