藥物交互作用
Amiodarone + Venetoclax
嚴重程度: 嚴重
Amiodarone and Venetoclax: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Amiodarone may increase venetoclax exposure, raising the risk of neutropenia and, in patients with high tumor burden, tumor lysis syndrome. Both CYP3A and P-gp inhibition contribute to this effect.
用白話說明這項交互作用的意義
Amiodarone and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
為什麼會發生
Amiodarone inhibits CYP3A4 and P-gp, decreasing venetoclax metabolism and efflux.
處置方式
Avoid if possible; otherwise reduce the venetoclax dose by at least 50% and monitor blood counts and for tumor lysis. Resume the prior dose after the inhibitor has been cleared, noting the long amiodarone half-life.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Venetoclax 的其他交互作用
常見問題
Can I take Amiodarone with Venetoclax?
MediHelp rates the interaction as major. Amiodarone and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may increase venetoclax exposure, raising the risk of neutropenia and, in patients with high tumor burden, tumor lysis syndrome. Both CYP3A and P-gp inhibition contribute to this effect.
How serious is the interaction between Amiodarone and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the venetoclax dose by at least 50% and monitor blood counts and for tumor lysis. Resume the prior dose after the inhibitor has been cleared, noting the long amiodarone half-life.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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