藥物交互作用
Aprepitant + Venetoclax
嚴重程度: 嚴重
Aprepitant and Venetoclax: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Aprepitant can increase venetoclax exposure, raising the risk of neutropenia and, in initiation phases, tumor lysis syndrome.
用白話說明這項交互作用的意義
Aprepitant and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Venetoclax belongs to Miscellaneous.
為什麼會發生
Aprepitant inhibits CYP3A4 metabolism of venetoclax.
處置方式
Avoid if possible; if needed, reduce the venetoclax dose by at least 50% and monitor blood counts and for tumor lysis. Resume the usual dose a few days after stopping aprepitant.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Aprepitant 的其他交互作用
Venetoclax 的其他交互作用
常見問題
Can I take Aprepitant with Venetoclax?
MediHelp rates the interaction as major. Aprepitant and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant can increase venetoclax exposure, raising the risk of neutropenia and, in initiation phases, tumor lysis syndrome.
How serious is the interaction between Aprepitant and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, reduce the venetoclax dose by at least 50% and monitor blood counts and for tumor lysis. Resume the usual dose a few days after stopping aprepitant.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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